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Bergen, V. ; Soldatov, R.A.* ; Kharchenko, P.V.* ; Theis, F.J.

RNA velocity-current challenges and future perspectives.

Mol. Syst. Biol. 17:e10282 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
RNA velocity has enabled the recovery of directed dynamic information from single-cell transcriptomics by connecting measurements to the underlying kinetics of gene expression. This approach has opened up new ways of studying cellular dynamics. Here, we review the current state of RNA velocity modeling approaches, discuss various examples illustrating limitations and potential pitfalls, and provide guidance on how the ensuing challenges may be addressed. We then outline future directions on how to generalize the concept of RNA velocity to a wider variety of biological systems and modalities.
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Publication type Article: Journal article
Document type Review
Keywords Rna Velocity ; Challenges ; Dynamics ; Limitations ; Perspectives; Single-cell; Gene-expression
ISSN (print) / ISBN 1744-4292
e-ISSN 1744-4292
Quellenangaben Volume: 17, Issue: 8, Pages: , Article Number: e10282 Supplement: ,
Publisher EMBO Press
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Grants EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
National Science Foundation (NSF)
Helmholtz Association ()
Deutsche Forschungsgemeinschaft (DFG)