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Nati, M. ; Chung, K.J.* ; Chavakis, T.

The role of innate immune cells in nonalcoholic fatty liver disease.

J. Innate Immun., 1-11 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and is linked to obesity and related conditions, such as the metabolic syndrome. When hepatic steatosis is accompanied by inflammation, the disorder is defined as nonalcoholic steatohepatitis (NASH), which in turn can progress toward fibrosis development that can ultimately result in cirrhosis. Cells of innate immunity, such as neutrophils or macrophages, are central regulators of NASH-related inflammation. Recent studies utilizing new experimental technologies, such as single-cell RNA sequencing, have revealed substantial heterogeneity within the macrophage populations of the liver, suggesting distinct functions of liver-resident Kupffer cells and recruited monocyte-derived macrophages with regards to regulation of liver inflammation and progression of NASH pathogenesis. Herein, we discuss recent developments concerning the function of innate immune cell subsets in NAFLD and NASH.
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Publication type Article: Journal article
Document type Review
Keywords Inflammation ; Macrophages ; Neutrophils ; Non-alcoholic Fatty Liver Disease; Necrosis-factor-alpha; Induced Hepatic Steatosis; Crown-like Structures; Kupffer Cells; Neutrophil Elastase; Early-stage; Receptor 4; Cholesterol Crystals; Oxidative Stress; Stellate Cells
ISSN (print) / ISBN 1662-811X
e-ISSN 1662-8128
Quellenangaben Volume: , Issue: , Pages: 1-11 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)
Grants Else Kroner Fresenius Center for Digital Health Dresden
German Ministry of Research and Education (BMBF)
National Institute of Dental and Craniofacial Research/National Institutes of Health (NIDCR/NIH)
German Research Foundation (DFG)
European Research Council (ERC)