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Seiringer, P. ; Garzorz-Stark, N.* ; Eyerich, K.*

T-cell‒mediated autoimmunity: Mechanisms and future directions.

J. Invest. Dermatol., DOI: 10.1016/j.jid.2021.04.032 (2021)
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T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in producing autoantibodies. Technological advances have contributed to identifying autoantigens, the Holy Grail of autoimmunity, in many inflammatory disorders of the skin. Novel therapeutic approaches such as chimeric (auto)antibody receptor T cells are a milestone on the way to finding individualized, well-tolerated, targeted therapies. This review summarizes the current knowledge on pathogenesis, immune response pattern‒related ontology, diagnostic approaches, and treatment options of autoimmune skin diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
ISSN (print) / ISBN 0022-202X
e-ISSN 1523-1747
Verlag Elsevier
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed