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Urbano, T.* ; Filippini, T.* ; Lasagni, D.* ; De Luca, T.* ; Grill, P. ; Sucato, S.* ; Polledri, E.* ; Noumbi, G.D.* ; Malavolti, M.* ; Santachiara, A.* ; Pertinhez, T.A.* ; Baricchi, R.* ; Fustinoni, S.* ; Michalke, B. ; Vinceti, M.*

Association of urinary and dietary selenium and of serum selenium species with serum alanine aminotransferase in a healthy italian population.

Antioxidants 10:1516 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
The trace element selenium is of considerable interest due to its toxic and nutritional properties, which markedly differ according to the dose and the chemical form. It has been shown that excess selenium intake increases the risk of type 2 diabetes and, possibly, other metabolic diseases like hyperlipidemia and non-alcoholic fatty liver disease (NAFLD). For the latter, however, epidemiologic evidence is still limited. We carried out a cross-sectional study recruiting 137 healthy blood donors living in Northern Italy and assessed their exposure to selenium through different methods and measuring serum selenium species. We performed linear and spline regression analyses to assess the relation of selenium and its forms with serum alanine aminotransferase (ALT) levels, a marker of NAFLD. Urinary selenium levels were positively and somewhat linearly correlated with ALT (beta regression coefficient (β) 0.11). Conversely, the association of dietary selenium intake with ALT was positive up to 100 µg/day and null above that amount (β 0.03). Total serum selenium was inversely associated with ALT up to 120 µg/L, and slightly positive above that amount. Concerning the different serum selenium species, ALT positively correlated with two organic forms, selenocysteine (β 0.27) and glutathione peroxidase-bound selenium (β 0.09), showed a U-shaped relation with the inorganic tetravalent form, selenite, and an inverse association with human serum albumin-bound selenium (β −0.56). Our results suggest that overall exposure to selenium, and more specifically to some of its chemical forms, is positively associated with ALT, even at levels so far generally considered to be safe. Our findings add to the evidence suggesting that low-dose selenium overexposure is associated with NAFLD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Alanine Aminotransferase ; Epidemiology ; Exposure ; Non-alcoholic Fatty Liver Disease ; Selenium ; Selenium Species; Vitamin-e; Selenoprotein-p; Prostate-cancer; Risk; Prevention; Trial; Speciation; Supplementation; Quantification; Metabolism
ISSN (print) / ISBN 2076-3921
e-ISSN 2076-3921
Journal Antioxidants
Quellenangaben Volume: 10, Issue: 10, Pages: , Article Number: 1516 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Grants Reggio Emilia Health Authority of the National Health Service
Italian Ministry of Education, University and Research
grant Dipartimenti di Eccellenza 20182022