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Steenblock, C.* ; Schwarz, P.E. ; Ludwig, B. ; Linkermann, A.* ; Zimmet, P.* ; Kulebyakin, K.* ; Tkachuk, V.A.* ; Markov, A.G.* ; Lehnert, H.* ; Hrabě de Angelis, M. ; Rietzsch, H.* ; Rodionov, R.N.* ; Khunti, K.* ; Hopkins, D.* ; Birkenfeld, A.L. ; Boehm, B.* ; Holt, R.I.G.* ; Skyler, J.S.* ; deVries, J.H.* ; Renard, E.* ; Eckel, R.H.* ; Alberti, K.G.M.M.* ; Geloneze, B.* ; Chan, J.C.* ; Mbanya, J.C.* ; Onyegbutulem, H.C.* ; Ramachandran, A.* ; Basit, A.* ; Hassanein, M.T.* ; Bewick, G.A.* ; Spinas, G.A.* ; Beuschlein, F.* ; Landgraf, R.* ; Rubino, F.* ; Mingrone, G.* ; Bornstein, S.R.

COVID-19 and metabolic disease: Mechanisms and clinical management.

Lancet Diabet. Endocrinol. 9, 786-798 (2021)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Insulin-resistance; Risk-factors; Inflammation; Association; Outcomes; Obesity; Ace2; Mortality; People; Prevention
ISSN (print) / ISBN 2213-8587
e-ISSN 2213-8595
Quellenangaben Band: 9, Heft: 11, Seiten: 786-798 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Begutachtungsstatus Peer reviewed
Förderungen DFG
Deutsche Forschungsgemeinschaft, a German Research foundation