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Kunzke, T. ; Prade, V.M. ; Buck, A. ; Sun, N. ; Feuchtinger, A. ; Matzka, M. ; Fernandez, I.E.* ; Wuyts, W.A.* ; Ackermann, M.* ; Jonigk, D.* ; Aichler, M. ; Schmid, R.A.* ; Eickelberg, O.* ; Berezowska, S.* ; Walch, A.K.

Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology.

Cancer Res. 81, 5862-5875 (2021)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiological significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorption/ionization (MALDI) fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging analysis, we discovered noxious carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines, or aromatic amines, in a series of 330 lung cancer patients in highly variable and unique patterns. The characteristic nature of carbon-bound exogenous compound had a strong association with patient outcome, tumor progression, the tumor immune microenvironment, PD-L1 expression, and DNA damage. Spatial correlation network analyses revealed substantial differences in the metabolome of tumor cells compared to tumor stroma depending on carbon-bound exogenous compounds. Overall, the bioactive pool of exogenous compounds is associated with several changes in lung cancer pathophysiology and correlates with patient outcome. Given the high prevalence of anthracosis in the lungs of adult humans, future work should investigate the role of carbon-bound exogenous compounds in lung carcinogenesis and lung cancer therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Polycyclic Aromatic-hydrocarbons; Imaging Mass-spectrometry; Pulmonary-fibrosis; Retention; Particles; Smoking; Risk
ISSN (print) / ISBN 0008-5472
e-ISSN 1538-7445
Zeitschrift Cancer Research
Quellenangaben Band: 81, Heft: 23, Seiten: 5862-5875 Artikelnummer: , Supplement: ,
Verlag American Association for Cancer Research (AACR)
Verlagsort Philadelphia, Pa.
Begutachtungsstatus Peer reviewed
Förderungen Helmholtz Zentrum Munchen
Impulse and Networking Fund of the Helmholtz Association
Deutsche Krebshilfe
Deutsche Forschungsgemeinschaft
Ministry of Education and Research of the Federal Republic of Germany (BMBF)