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Return to homeostasis: Downregulation of NF-κB responses.
Nat. Immunol. 12, 709-714 (2011)
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords t-cell-activation; alpha-mediated phosphorylation; negative feedback loop; editing enzyme a20; ikk-alpha; irak-m; deubiquitinating enzyme; gene-expression; innate immunity; signaling pathway
ISSN (print) / ISBN 1529-2908
Journal Nature Immunology
Quellenangaben Volume: 12, Issue: 8, Pages: 709-714
Publisher Nature Publishing Group
Publishing Place New York, NY, USA
Reviewing status Peer reviewed