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Sato, S.* ; Dyar, K.A. ; Treebak, J.T.* ; Jepsen, S.L.* ; Ehrlich, A.M.* ; Ashcroft, S.P.* ; Trost, K.* ; Kunzke, T. ; Prade, V.M. ; Small, L.* ; Basse, A.L.* ; Schönke, M.* ; Chen, S.* ; Samad, M.* ; Baldi, P.* ; Barrès, R.* ; Walch, A.K. ; Moritz, T.* ; Holst, J.J.* ; Lutter, D. ; Zierath, J.R.* ; Sassone-Corsi, P.*

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.

Cell Metab. 34, 329-345.e8 (2022)
Publ. Version/Full Text Research data DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 2-hydroxybutyrate ; Arteriovenous Metabolomics ; Circadian Rhythms ; Exercise Metabolism ; Exerkines ; Metabolomics ; Multitissue Analysis
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 34, Issue: 2, Pages: 329-345.e8 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Grants National Institute of Health
Deutsches Zentrum fur Diabetesforschung (DZD)
Helmholtz Association