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Measuring technique for thermal ionisation mass spectrometry of human tracer kinetic study with stable cerium isotopes.
Isotopes Environ. Health Stud. 47, 238-252 (2011)
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Thermal ionisation mass spectrometry (TIMS) method has been developed for the simultaneous detection of different cerium isotopes in biological samples (i.e., blood and urine) at very low concentrations. The work has been done in the frame of a biokinetic study, where different stable cerium isotopes have been administered orally and intravenously as tracers to the human body. In order to develop an appropriate detection method for the tracers in the biological samples, an optimum sample preparation technique has been set and adapted to the specific requirements of the analysis technique used, i.e., TIMS. For sample evaporation and ionisation, the double tantalum filament technique showed the best results. The ions produced were simultaneously collected on a secondary electron multiplier so that the isotopic ratios of the cerium isotopes in the biological samples could be measured. The technique has been optimised for the determination of cerium down to 1 ng loaded on the evaporation filament corresponding to cerium concentrations of down to 1 ng ml(-1) in the blood or urine samples. It has been shown that the technique is reliable in application and enables studies on cerium metabolism and biokinetics in humans without employing radioactive tracers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter thermal ionisation mass spectrometry (TIMS); double tracer technique; isotope measurement; methods and equipment; blood; sample preparation; urine; cerium-136; cerium-138; cerium-142
ISSN (print) / ISBN 1025-6016
Zeitschrift Isotopes in Environmental and Health Studies
Quellenangaben Band: 47, Heft: 2, Seiten: 238-252
Verlag Taylor & Francis
Begutachtungsstatus Peer reviewed