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Friedland, W. ; Dingfelder, M.* ; Kundrát, P. ; Jacob, P.

Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC.

Mutat. Res. -Fund. Mol. Mech. Mutag. 711, 28-40 (2011)
Open Access Green as soon as Postprint is submitted to ZB.
This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fibroblasts and lymphocytes in atomic resolution. Calculation methods and essential results are recapitulated regarding the physical, physico-chemical and chemical stage of track structure development of radiation damage induction. Recent model extension towards DNA repair processes extends the time dimension by about 12 orders of magnitude and paves the way for superior predictions of radiation risks.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Modelling; Track structure; Multi-scale; DNA damage; DNA repair
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Quellenangaben Volume: 711, Issue: 1-2, Pages: 28-40 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed