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Bergmann, C.* ; Poli, A.* ; Agache, I.* ; Bianchini, R.* ; Bax, H.J.* ; Castells, M.* ; Crescioli, S.* ; Dombrowicz, D.* ; Ferastraoaru, D.* ; Fiebiger, E.* ; Gould, H.J.* ; Hartmann, K.* ; Izquierdo, E.* ; Jordakieva, G.* ; Josephs, D.H.* ; Jutel, M.* ; Levi-Schaffer, F.* ; De las Vecillas, L.* ; Lotze, M.T.* ; Osborn, G.* ; Pascal, M.* ; Redegeld, F.* ; Rosenstreich, D.* ; Roth-Walter, F.* ; Schmidt-Weber, C.B. ; Shamji, M.* ; Steveling, E.H.* ; Turner, M.C.* ; Untersmayr, E.* ; Jensen-Jarolim, E.* ; Karagiannis, S.N.*

AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper.

Allergy, DOI: 10.1111/all.15255 (2022)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The immune system interacts with many nominal 'danger' signals, endogenous danger-associated (DAMP), exogenous pathogen (PAMP) and allergen (AAMP)-associated molecular pattern molecules. The immune context under which these are received can promote or prevent immune activating or inflammatory mechanisms and may orchestrate diverse immune responses in allergy and cancer. Each can act either by favouring a respective pathology or by supporting the immune response to confer protective effects, depending on acuity or chronicity. In this Position Paper under the collective term danger signals or DAMPs, PAMPs, and AAMPs, we consider their diverse roles in allergy and cancer and the connection between these in AllergoOncology. We focus on their interactions with different immune cells of the innate and adaptive immune system and how these promote immune responses with juxtaposing clinical outcomes in allergy and cancer. While danger signals present potential targets to overcome inflammatory responses in allergy, these may be reconsidered in relation to a history of allergy, chronic inflammation and autoimmunity linked to the risk of developing cancer, and with regards to clinical responses to anti-cancer immune and targeted therapies. Cross-disciplinary insights in AllergoOncology derived from dissecting clinical phenotypes of common danger signal pathways may improve allergy and cancer clinical outcomes.
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Publication type Article: Journal article
Document type Review
Keywords Aamp ; Alr ; Damp ; Danger Signals ; Nlr ; Pamp ; Rlr ; Tlr ; Allergy ; Cancer ; Immune Response ; Immunotherapy ; Inflammation ; Tolerance
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Publisher Wiley
Reviewing status Peer reviewed
Grants Medical Research Council
European Academy for Allergy and Clinical Immunology (EAACI)