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Sims, E.K.* ; Besser, R.E.J.* ; Dayan, C.* ; Geno Rasmussen, C.* ; Greenbaum, C.J.* ; Griffin, K.J.* ; Hagopian, W.* ; Knip, M.* ; Long, A.E.* ; Martin, F.* ; Mathieu, C.* ; Rewers, M.* ; Steck, A.K.* ; Wentworth, J.M.* ; Rich, S.S.* ; Kordonouri, O.* ; Ziegler, A.-G. ; Herold, K.C.*

Screening for type 1 diabetes in the general population: A status report and perspective.

Diabetes 71, 610-623 (2022)
Free by publisher: Publ. Version/Full Text online available 05/2023
Most screening programs to identify individuals at risk for type 1 diabetes have targeted relatives of people living with the disease to improve yield and feasibility. However, ∼90% of those who develop type 1 diabetes do not have a family history. Recent successes in disease-modifying therapies to impact the course of early-stage disease have ignited the consideration of the need for and feasibility of population screening to identify those at increased risk. Existing population screening programs rely on genetic or autoantibody screening, and these have yielded significant information about disease progression and approaches for timing for screening in clinical practice. At the March 2021 Type 1 Diabetes TrialNet Steering Committee meeting, a session was held in which ongoing efforts for screening in the general population were discussed. This report reviews the background of these efforts and the details of those programs. Additionally, we present hurdles that need to be addressed for successful implementation of population screening and provide initial recommendations for individuals with positive screens so that standardized guidelines for monitoring and follow-up can be established.
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Publication type Article: Journal article
Document type Review
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 71, Issue: 4, Pages: 610-623 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Grants Eunice Kennedy Shriver National Institute of Child Health and Human Development
Juvenile Diabetes Research Foundation United States of America
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health