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Matheus, F. ; Raveh, T.* ; Oro, A.E.* ; Wernig, M.* ; Drukker, M.

Is hypoimmunogenic stem cell therapy safe in times of pandemics?

Stem Cell Rep. 17, 711-714 (2022)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should “universal” grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
ISSN (print) / ISBN 2213-6711
Zeitschrift Stem Cell Reports
Quellenangaben Band: 17, Heft: 4, Seiten: 711-714 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Maryland Heights, MO
Begutachtungsstatus Peer reviewed