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Pfeufer, A. ; van Noord, C.* ; Marciante, K.D.* ; Arking, D.E.* ; Larson, M.G.* ; Smith, A.V.* ; Tarasov, K.V.* ; Müller, M. ; Sotoodehnia, N.* ; Sinner, M.F.* ; Verwoert, G.C.* ; Li, M.* ; Kao, W.H.L.* ; Köttgen, A.* ; Coresh, J.* ; Bis, J.C.* ; Psaty, B.M.* ; Rice, K.* ; Rotter, J.I.* ; Rivadeneira, F.* ; Hofman, A.* ; Kors, J.A.* ; Stricker, B.H.C.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; Beckmann, B.M.* ; Sauter, W. ; Gieger, C. ; Lubitz, S.A.* ; Newton-Cheh, C.* ; Wang, T.J.* ; Magnani, J.W.* ; Schnabel, R.B.* ; Chung, M.K.* ; Barnard, J.* ; Smith, J.D.* ; van Wagoner, D.R.* ; Vasan, R.S.* ; Aspelund, T.* ; Eiriksdottir, G.* ; Harris, T.B.* ; Launer, L.J.* ; Najjar, S.S.* ; Lakatta, E.* ; Schlessinger, D.* ; Uda, M.* ; Abecasis, G.R.* ; Müller-Myhsok, B.* ; Ehret, G.B.* ; Boerwinkle, E.* ; Chakravarti, A.* ; Soliman, E.Z.* ; Lunetta, K.L.* ; Perz, S. ; Wichmann, H.-E. ; Meitinger, T. ; Levy, D.* ; Gudnason, V.* ; Ellinor, P.T.* ; Sanna, S.* ; Kääb, S.* ; Witteman, J.C.M.* ; Alonso, A.* ; Benjamin, E.J.* ; Heckbert, S.R.*

Genome-wide association study of PR interval.

Nat. Genet. 42, 153-159 (2010)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Atrial-fibrillation; Common variants; Sodium-channel; Heart-rate; Atherosclerosis risk; National heart; System; Design; Individuals; Variability
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 42, Heft: 2, Seiten: 153-159 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed