PuSH - Publication Server of Helmholtz Zentrum München

van Dam, G.M.* ; Themelis, G. ; Crane, L.M.* ; Harlaar, N.J. ; Pleijhuis, R.G.* ; Kelder, W.* ; Sarantopoulos, A. ; de Jong, J.S.* ; Arts, H.J.* ; van der Zee, A.G.* ; Bart, J.* ; Low, P.S.* ; Ntziachristos, V.

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results.

J. Nat. Med. 17, 1315-1319 (2011)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
Altmetric
Additional Metrics?
Tags
Highlight IBMI
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords no keywords
ISSN (print) / ISBN 1340-3443
e-ISSN 1861-0293
Quellenangaben Volume: 17, Issue: 10, Pages: 1315-1319 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Tokyo [u.a.]
Reviewing status Peer reviewed