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Cadby, G.* ; Giles, C.* ; Melton, P.E.* ; Huynh, K.* ; Mellett, N.A.* ; Duong, T.* ; Nguyen, A.* ; Cinel, M.* ; Smith, A.* ; Olshansky, G.* ; Wang, T.* ; Brozynska, M.* ; Inouye, M.* ; McCarthy, N.S.* ; Ariff, A.* ; Hung, J.* ; Hui, J.* ; Beilby, J.* ; Dubé, M.P.* ; Watts, G.F.* ; Shah, S.* ; Wray, N.R.* ; Lim, W.L.F.* ; Chatterjee, P.* ; Martins, I.* ; Laws, S.M.* ; Porter, T.* ; Vacher, M.* ; Bush, A.I.* ; Rowe, C.C.* ; Villemagne, V.L.* ; Ames, D.* ; Masters, C.L.* ; Taddei, K.* ; Arnold, M. ; Kastenmüller, G. ; Nho, K.* ; Saykin, A.J.* ; Han, X.* ; Kaddurah-Daouk, R.* ; Martins, R.N.* ; Blangero, J.* ; Meikle, P.J.* ; Moses, E.K.*

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.

Nat. Commun. 13:3124 (2022)
Verlagsversion Forschungsdaten Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P < 1 × 10-3), 43 loci were associated with at least one lipid endophenotype. These findings illustrate the value of integrative biology to investigate the aetiology of atherosclerosis and CAD, with implications for other complex diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 3124 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed