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Pardo, M.* ; Offer, S. ; Hartner, E. ; Di Bucchianico, S. ; Bisig, B. ; Bauer, S. ; Pantzke, J. ; Zimmermann, E. ; Cao, X. ; Binder, S. ; Kuhn, E. ; Huber, A. ; Jeong, S. ; Käfer, U. ; Schneider, E.* ; Mesceriakovas, A.* ; Bendl, J. ; Brejcha, R. ; Buchholz, A.* ; Gat, D.* ; Hohaus, T.* ; Rastak, N. ; Karg, E.W. ; Jakobi, G. ; Kalberer, M.* ; Kanashova, T.* ; Hu, Y. ; Ogris, C. ; Marsico, A. ; Theis, F.J. ; Shalit, T.* ; Gröger, T.M. ; Rüger, C.P.* ; Oeder, S. ; Orasche, J. ; Paul, A.* ; Ziehm, T.* ; Zhang, Z.H.* ; Adam, T. ; Sippula, O.* ; Sklorz, M. ; Schnelle-Kreis, J. ; Czech, H. ; Kiendler-Scharr, A.* ; Zimmermann, R. ; Rudich, Y.*

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.

Environ. Int. 166:107366 (2022)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities of soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) and SP coated with naphthalene SOA (SOANap-SP) in a human bronchial epithelial cell line (BEAS-2B) residing at the air-liquid interface. SOAβPin-SP mostly contained oxygenated aliphatic compounds from β-pinene photooxidation, whereas SOANap-SP contained a significant fraction of oxygenated aromatic products under similar conditions. Following exposure, genome-wide transcriptome responses showed an Nrf2 oxidative stress response, particularly for SOANap-SP. Other signaling pathways, such as redox signaling, inflammatory signaling, and the involvement of matrix metalloproteinase, were identified to have a stronger impact following exposure to SOANap-SP. SOANap-SP also induced a stronger genotoxicity response than that of SOAβPin-SP. This study elucidated the mechanisms that govern SOA toxicity and showed that, compared to SOAs derived from a typical biogenic precursor, SOAs from a typical anthropogenic precursor have higher toxicological potency, which was accompanied with the activation of varied cellular mechanisms, such as aryl hydrocarbon receptor. This can be attributed to the difference in chemical composition; specifically, the aromatic compounds in the naphthalene-derived SOA had higher cytotoxic potential than that of the β-pinene-derived SOA.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cytotoxicity ; Health Effects ; Particulate Matter ; Rna Sequencing ; Signaling Pathway ; Soot Particles
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Quellenangaben Band: 166, Heft: , Seiten: , Artikelnummer: 107366 Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed