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The sound of drug delivery: Optoacoustic imaging in pharmacology.

Adv. Drug Deliv. Rev. 189:114506 (2022)
Open Access Green: Postprint online verfügbar 11/2023
Optoacoustic (photoacoustic) imaging offers unique opportunities for visualizing biological function in vivo by achieving high-resolution images of optical contrast much deeper than any other optical technique. The method detects ultrasound waves that are generated inside tissue by thermo-elastic expansion, i.e., the conversion of light absorption by tissue structures to ultrasound when the tissue is illuminated by the light of varying intensity. Listening instead of looking to light offers the major advantage of image formation with a resolution that obeys ultrasonic diffraction and not photon diffusion laws. While the technique has been widely used to explore contrast from endogenous photo-absorbing molecules, such as hemoglobin or melanin, the use of exogenous agents can extend applications to a larger range of biological and possible clinical applications, such as image-guided surgery, disease monitoring, and the evaluation of drug delivery, biodistribution, and kinetics. This review summarizes recent developments in optoacoustic agents, and highlights new functions visualized and potent pharmacology applications enabled with the use of external contrast agents.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Bio-inspired Agents ; Drug Delivery ; Optoacoustics (photoacoustics) ; Synthetic Agents ; Theranostics
ISSN (print) / ISBN 0169-409X
e-ISSN 1872-8294
Quellenangaben Band: 189, Heft: , Seiten: , Artikelnummer: 114506 Supplement: ,
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Förderungen Deutsche Forschungsgemeinschaft