PuSH - Publikationsserver des Helmholtz Zentrums München

Trares, K.* ; Bhardwaj, M.* ; Perna, L.* ; Stocker, H.R.* ; Petrera, A. ; Hauck, S.M. ; Beyreuther, K.* ; Brenner, H.* ; Schöttker, B.*

Association of the inflammation-related proteome with dementia development at older age: Results from a large, prospective, population-based cohort study.

Alzheimers Res. Ther. 14:128 (2022)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet. METHODS: The Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000-06/2002) of 1782 older adults from a German, population-based cohort study in a case-cohort design. Logistic regression models were used to assess the associations of biomarkers with all-cause dementia, Alzheimer's disease, and vascular dementia incidence. RESULTS: During 17 years of follow-up, 504 participants were diagnosed with dementia, including 163 Alzheimer's disease and 195 vascular dementia cases. After correction for multiple testing, 58 out of 72 tested (80.6%) biomarkers were statistically significantly associated with all-cause dementia, 22 with Alzheimer's disease, and 33 with vascular dementia incidence. We identified four biomarker clusters, among which the strongest representatives, CX3CL1, EN-RAGE, LAP TGF-beta-1, and VEGF-A, were significantly associated with dementia endpoints independently from other inflammation-related proteins. CX3CL1 (odds ratio [95% confidence interval] per 1 standard deviation increase: 1.41 [1.24-1.60]) and EN-RAGE (1.41 [1.25-1.60]) were associated with all-cause dementia incidence, EN-RAGE (1.51 [1.25-1.83]) and LAP TGF-beta-1 (1.46 [1.21-1.76]) with Alzheimer's disease incidence, and VEGF-A (1.43 [1.20-1.70]) with vascular dementia incidence. All named associations were stronger among APOE ε4-negative subjects. CONCLUSION: With this large, population-based cohort study, we show for the first time that the majority of inflammation-related proteins measured in blood samples are associated with total dementia incidence. Future studies should concentrate not only on single biomarkers but also on the complex relationships in biomarker clusters.
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Alzheimer’s Disease ; Biomarker ; Cohort Study ; Dementia ; Inflammation ; Vascular Dementia
ISSN (print) / ISBN 1758-9193
e-ISSN 1758-9193
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 128 Supplement: ,
Verlag BioMed Central
Verlagsort London
Begutachtungsstatus Peer reviewed
Förderungen Bundesministerium für Bildung und Forschung
Ministerium fur Wissenschaft, Forschung und Kunst Baden-Wurttemberg
Ministerium für Soziales, Gesundheit, Frauen und Familie, Saarland
Bundesministerium für Familie, Senioren, Frauen und Jugend