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van Hoey, O.* ; Stolarczyk, L.* ; Lillhök, J.* ; Eliasson, L.* ; Mojzeszek, N.* ; Liszka, M.* ; Alkhiat, A.* ; Mares, V. ; Trompier, F.* ; Trinkl, S. ; Martínez-Rovira, I.* ; Romero-Expósito, M.* ; Domingo, C.* ; Ploc, O.* ; Harrison, R.* ; Olko, P.*

Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters.

Front. Oncol. 12:903537 (2022)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Monte Carlo Simulations ; Neutron Doses ; Neutron Measurements ; Out-of-field Neutron Doses In Radiation Therapy ; Pencil Beam Scanned Proton Therapy ; Proton Therapy
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Zeitschrift Frontiers in Oncology
Quellenangaben Band: 12, Heft: , Seiten: , Artikelnummer: 903537 Supplement: ,
Verlag Frontiers
Begutachtungsstatus Peer reviewed
Förderungen Horizon 2020
European External Action Service
Ministerio de Ciencia, Innovación y Universidades