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Chang, S.* ; Fermani, F.* ; Lao, C.L.* ; Huang, L. ; Jakovcevski, M.* ; Di Giaimo, R.* ; Gagliardi, M.* ; Menegaz, D.* ; Hennrich, A.A.* ; Ziller, M.J.* ; Eder, M.* ; Klein, R.* ; Cai, N. ; Deussing, J.M.*

Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior.

Sci. Adv. 8:eabo1023 (2022)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra (SN). Specific stimulation of this circuit elicits hyperactivation of the hypothalamic-pituitary-adrenal axis, locomotor activation, and avoidance behavior contingent on CRH receptor type 1 (CRHR1) located at axon terminals in the SN, which originate from external globus pallidus (GPe) neurons. The neuronal activity prompting the observed behavior is shaped by IPACLCRH and GPeCRHR1 neurons coalescing in the SN. These results delineate a previously unidentified tripartite CRH circuit functionally connecting extended amygdala and basal ganglia nuclei to drive locomotor activation and avoidance behavior.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 8, Heft: 46, Seiten: , Artikelnummer: eabo1023 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
Förderungen Max-Planck-Gesellschaft
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
European Research Council
Marie Skłodowska-Curie innovative training network PurinesDX