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Norton, W.H.J. ; Stumpenhorst, K. ; Faus-Kessler, T. ; Folchert, A. ; Rohner, N.* ; Harris, M.P.* ; Callebert, J.* ; Bally-Cuif, L.

Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome.

J. Neurosci. 31, 13796-13807 (2011)
Open Access Green as soon as Postprint is submitted to ZB.
Behavioral syndromes are suites of two or more behaviors that correlate across environmental contexts. The aggression-boldness syndrome links aggression, boldness, and exploratory activity in a novel environment. Although aggression-boldness has been described in many animals, the mechanism linking its behavioral components is not known. Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a (fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish. We demonstrate that altered Fgf signaling also results in reduced brain histamine levels in mutants. Pharmacological increase of histamine signaling is sufficient to rescue the behavioral phenotype of fgfr1a mutants. Together, we show that a single genetic locus can underlie the aggression-boldness behavioral syndrome. We also identify one of the neurotransmitter pathways that may mediate clustering of these behaviors.
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Publication type Article: Journal article
Document type Scientific Article
Keywords histamine h-3 receptor; fish danio-rerio; behavioral syndromes; gasterosteus-aculeatus; 3-spined stickleback; therapeutic target; betta-splendens; brain; expression; system
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Quellenangaben Volume: 31, Issue: 39, Pages: 13796-13807 Article Number: , Supplement: ,
Publisher Society for Neuroscience
Publishing Place Washington, DC, USA
Reviewing status Peer reviewed