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Yoo, H.* ; Kim, J.W.* ; Shishkov, M.* ; Namati, E.* ; Morse, T.* ; Shubochkin, R.* ; McCarthy, J.R.* ; Ntziachristos, V. ; Bouma, B.E.* ; Jaffer, F.A.* ; Tearney, G.J.*

Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo.

J. Nat. Med. 17, 1680-1684 (2011)
Open Access Green as soon as Postprint is submitted to ZB.
Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.
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Publication type Article: Journal article
Document type Scientific Article
Keywords no keywords
ISSN (print) / ISBN 1340-3443
e-ISSN 1861-0293
Quellenangaben Volume: 17, Issue: 12, Pages: 1680-1684 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Tokyo [u.a.]
Reviewing status Peer reviewed