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Early determinants of type 1 diabetes: Experience from the BABYDIAB and BABYDIET studies.

Am. J. Clin. Nutr. 94, 1821-1823 (2011)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
Type 1 diabetes is an immune-mediated disorder that results from progressive destruction of the islet β cells. A genetic susceptibility for the development of islet autoimmunity and type 1 diabetes is well documented, and an environmental influence is assumed. Prospective studies from birth have shown that islet autoimmunity occurs very early in life, which implies that fetal or postnatal environmental factors may program the development of islet autoimmunity. In this overview, results from the BABYDIAB study, a prospective study from birth on the natural history of type 1 diabetes, and the BABYDIET study, a dietary intervention study, are discussed with a focus on the role of a diabetes environment in utero and the role of early gluten exposure on islet autoimmunity risk in children.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Islet autoantibodies; Incidence trends; Risk; Autoimmunity; Children; Mothers; Mice; Appearance; Exposure; Insulin
ISSN (print) / ISBN 0002-9165
e-ISSN 1938-3207
Quellenangaben Volume: 94, Issue: 6, Pages: 1821-1823 Article Number: , Supplement: ,
Publisher American Society for Nutrition
Reviewing status Peer reviewed