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Sox10-iCreERT2 : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.

Genesis 50, 506-515 (2012)
Open Access Green as soon as Postprint is submitted to ZB.
SOX10 is a well-conserved and widely expressed transcription factor involved in the regulation of embryonic development and in the determination of cell fate. As it is expressed in neural crest cells, their derivatives and the oligodendrocyte lineage, mutations of the protein contribute to a variety of diseases like neurocristopathies, peripheral demyelinating neuropathies and melanoma. Here, we report the generation of an inducible Sox10-iCreER(T2) BAC transgenic mouse line that labels, depending on the timepoint of induction, distinct derivatives of the otic placode and the neural crest as well as cells of the oligodendrocyte lineage. Surprisingly, we could show a neural crest origin of pericytes in the brain. Besides its use for fate-mapping, the Sox10-iCreER(T2) mouse line is a powerful tool to conditionally inactivate genes in the neural crest cells, its progeny and/or the oligodendrocyte lineage in a time-dependent fashion to gain further insights into their function and contribution to diseases.
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Publication type Article: Journal article
Document type Scientific Article
Keywords NG2; fate mapping; BAC-transgenic; lineage; pericytes
ISSN (print) / ISBN 1526-954X
e-ISSN 1526-968X
Quellenangaben Volume: 50, Issue: 6, Pages: 506-515 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed