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Mallas, G.* ; Rosenthal, A. ; Calfon, M.A.* ; Razansky, R.N. ; Mauskapf, A.* ; Jaffer, F.A.* ; Brooks, D.H.* ; Ntziachristos, V.

Progress on multimodal molecular / anatomical intravascular imaging of coronary vessels combining near infrared fluorescence and ultrasound.

In: Proceedings (33rd Annual International Conference of the IEEE EMBS, 30th August - 3rd September 2011, Boston, USA). Piscataway, NJ: IEEE, 2011. 1117-1120
DOI
The use of intravascular imaging modalities for the detection and assessment of atherosclerotic plaque is becoming increasingly useful. Current clinical invasive modalities assess the presence of plaque using anatomical information and include Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT). However, such modalities cannot take into account underlying functional biological information, which can however be revealed with the use of molecular imaging. Consequently, intravascular molecular imaging is emerging as a powerful approach. We have developed such a Near-Infrared Fluorescence (NIRF) imaging system and showcased, in both phantom and in-vivo (rabbit) experiments, its potential to successfully detect inflamed atherosclerotic plaques, using appropriate fluorescent probes. Here, we discuss some limitations of the current system and suggest the combined use of the NIRF and IVUS imaging systems as a means for more accurate assessment of atherosclerotic plaque. We include some results and models that showcase the potential power of this kind of hybrid imaging.
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Publication type Article: Conference contribution
Keywords no keywords
ISBN 978-1-4244-4122-8
Conference Title 33rd Annual International Conference of the IEEE EMBS
Conference Date 30th August - 3rd September 2011
Conference Location Boston, USA
Proceedings Title Proceedings
Quellenangaben Volume: , Issue: , Pages: 1117-1120 Article Number: , Supplement: ,
Publisher IEEE
Publishing Place Piscataway, NJ