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Rzehak, P. ; Sausenthaler, S. ; Koletzko, S.* ; Reinhardt, D.* ; von Berg, A.* ; Krämer, U.* ; Berdel, D.* ; Bollrath, C.* ; Grubl, A.* ; Bauer, C.P.* ; Wichmann, H.-E. ; Heinrich, J. ; GINIplus Study Group (Schoetzau, A. ; Popescu, M. ; Mosetter, M. ; Schindler, J. ; Franke, K. ; Laubereau, B. ; Thaqi, A. ; Zirngibl, A. ; Zutavern, A. ; Wichmann, H.-E. ; Heinrich, J.)

Long-term effects of hydrolyzed protein infant formulas on growth - extended follow-up to 10 y of age: Results from the German Infant Nutritional Intervention (GINI) study.

Am. J. Clin. Nutr. 94, Suppl., 1803S-1807S (2011)
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Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Previous analysis in a prospective, population-based cohort reported reduced weight gain in children fed extensively hydrolyzed casein (eHF-C) formula during the first year of life but showed no effect on growth between 1 and 6 y of life. No studies have been conducted in children up to the age of 10 y. OBJECTIVE: The objective was to investigate potential differences in body mass index (BMI) over the first 10 y of life between infants fed within the intervention period of the first 16 wk of life with partially hydrolyzed whey (pHF-W), extensively hydrolyzed whey (eHF-W), eHF-C, or cow-milk formula (CMF) and infants exclusively breastfed (BF) within the intervention period. DESIGN: This was a prospective, randomized, double-blind trial in full-term neonates with atopic heredity in the German birth cohort German Infant Nutritional Intervention (GINI) followed through the first 10 y of life. Analyses of absolute and World Health Organization (WHO)-standardized BMI trajectories for 1840 infants [pHF-W (n = 253), eHF-W (n = 265), eHF-C (n = 250), CMF (n = 276), and BF (n = 796)] were conducted according to intention-to-treat principles. RESULTS: Except for the previously reported slower BMI gain in infants fed with eHF-C formula within the first year of life, no significant differences in absolute or WHO-standardized BMI trajectories were shown between the pHF-W, eHF-W, eHF-C, CMF, and BF groups thereafter up to the age of 10 y. CONCLUSIONS: Extension of the follow-up period from 6 to 10 y for this randomized controlled trial showed no long-term consequences on BMI for the 4 infant formulas considered. These data need to be confirmed in future studies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Milk; Life; Childhood; Standards; Children; Obesity; Trail
ISSN (print) / ISBN 0002-9165
e-ISSN 1938-3207
Quellenangaben Volume: 94, Issue: 6, Pages: 1803S-1807S, Article Number: , Supplement: Suppl.
Publisher American Society for Nutrition
Reviewing status Peer reviewed