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Significance of Apoptosis in Hepatitis B Virus (HBV) Infection.

München, Technische Universität München, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2010, 191 S.
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HBV is a serious health problem with more than 2 billion people infected worldwide. The virus exclusively replicates in hepatocytes; its recognition by the immune system leads to liver inflammation, called hepatitis, with variable extent. This work focused on apoptosis of HBV-infected hepatocytes as an important cellular defence mechanism. (i) We generated a cell culture system consisting of HBV-producing hepatoma cell lines and primary human hepatocytes; through this we showed for the first time that apoptotic hepatocytes released huge amounts of non-infectious HBV particles. (ii) The increased resistance of HBV-producing cells towards apoptosis implies that HBV actively prevents apoptosis of its host cell. (iii) By the use of mouse model of an acute, self-limiting HBV infection using adenoviral vectors, we uncovered that CD95-induced apoptosis of infected hepatocytes is essential for priming the adaptive immune response against HBV.
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Publikationstyp Sonstiges: Hochschulschrift
Typ der Hochschulschrift Dissertationsschrift
Schlagwörter HBV; CD95-induced apoptosis; primary human hepatocytes; mouse model
Quellenangaben Band: , Heft: , Seiten: 191 S. Artikelnummer: , Supplement: ,
Hochschule Technische Universität München
Hochschulort München
Fakultät Fakultät Wissenschaftszentrum Weihenstephan