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Potential immune correlates of protection in HIV-1 infected individuals.

München, Technische Universität München, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2011, 107 S.
Verlagsversion Volltext
A major problem in the development of a vaccine against HIV is, that immunological correlates of protection remain still unknown. To identify such correlates, T-cell immune responses of HIV-1 infected patients with different control of viral replication were analyzed by polychromatic flowcytometry. A characteristic feature of nonprogressors, in comparison to progressors and patients under antiretroviral treatment, was the presence of HIV-1-nef-specific CD45RA+ CD8+ T cells secreting MIP-1β, but not IFN-γ. Furthermore, the T-cell response of an HIV-1 infected patient was investigated, who maintained stable viremia for three years, before control of viral replication was lost. Functional loss of HIV-1 specific CD4+ and CD8+ T cells, as well as a decrease of terminally differentiated CD8+ T cells correlated with loss of viral control. This study identifies possible correlates of protection and contributes to understand the mechanisms involved in the failure of the host immune system.
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Publikationstyp Sonstiges: Hochschulschrift
Typ der Hochschulschrift Dissertationsschrift
Schlagwörter HIV; T-cell response; HIV-infection; T-lymphocyte; immune response; vaccine protection
Quellenangaben Band: , Heft: , Seiten: 107 S. Artikelnummer: , Supplement: ,
Hochschule Technische Universität München
Hochschulort München
Fakultät Fakultät Wissenschaftszentrum Weihenstephan