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Bradfield, J.P.* ; Taal, H.R.* ; Timpson, N.J.* ; Scherag, A.* ; Lecoeur, C.* ; Warrington, N.M.* ; Hyppönen, E.* ; Holst, C.* ; Valcárcel, B.* ; Thiering, E. ; Salem, R.M.* ; Schumacher, F.R.* ; Cousminer, D.L.* ; Sleiman, P.M.* ; Zhao, J.H.* ; Berkowitz, R.I.* ; Vimaleswaran, K.S.* ; Jarick, I.* ; Pennell, C.E.* ; Evans, D.M.* ; St Pourcain, B.* ; Berry, D.J.* ; Mook-Kanamori, D.O.* ; Hofman, A.* ; Rivadeneira, F.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; van der Valk, R.J.* ; de Jongste, J.C.* ; Postma, D.S.* ; Boomsma, D.I.* ; Gauderman, W.J.* ; Hassanein, M.T.* ; Lindgren, C.M.* ; Mägi, R.* ; Boreham, C.A.* ; Neville, C.E.* ; Moreno, L.A.* ; Elliott, P.* ; Pouta, A.* ; Hartikainen, A.L.* ; Li, M.Y* ; Raitakari, O.* ; Lehtimäki, T.* ; Eriksson, J.G.* ; Palotie, A.* ; Dallongeville, J.* ; Das, S.* ; Deloukas, P.* ; McMahon, G.* ; Ring, S.M.* ; Kemp, J.P.* ; Buxton, J.L.* ; Blakemore, A.I.* ; Bustamante, M.* ; Guxens, M.* ; Hirschhorn, J.N.* ; Gillman, M.W.* ; Kreiner-Moller, E.* ; Bisgaard, H.* ; Gilliland, F.D.* ; Heinrich, J. ; Wheeler, E.* ; Barroso, I.* ; O'Rahilly, S.* ; Meirhaeghe, A.* ; Sorensen, T.I.* ; Power, C.* ; Palmer, L.J.* ; Hinney, A.* ; Widen, E.* ; Farooqi, I.S.* ; McCarthy, M.I.* ; Froguel, P.* ; Meyre, D.* ; Hebebrand, J.* ; Jarvelin, M.R.* ; Jaddoe, V.W.* ; Smith, G.D.* ; Hakonarson, H.* ; Grant, S.F.A.*

A genome-wide association meta-analysis identifies new childhood obesity loci.

Nat. Genet. 44, 526-531 (2012)
Publishers Version DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (>= 95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 x 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous metaanalysis of adult BMI1.
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Publication type Article: Journal article
Document type Scientific Article
Keywords BODY-MASS INDEX; HELICOBACTER-PYLORI; PREVENTION; OVERWEIGHT; BMI
Reviewing status