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Huang, L.R.* ; Gabel, Y.A.* ; Graf, S. ; Arzberger, S. ; Kurts, C.* ; Heikenwälder, M. ; Knolle, P.A.* ; Protzer, U.

Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Gastroenterology 142, 1447-1450 (2012)
Verlagsversion Volltext DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Studies of mechanisms responsible for the persistence of hepatitis B virus (HBV) infection have been hindered by a lack of appropriate animal models. HBV genomes can be delivered to livers of mice using hydrodynamic injection or high doses of an adenoviral vector; these lead to clearance of HBV. We found that infection of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection; the mice neither underwent seroconversion to production of antibodies against HBV nor developed a strong HBV-specific effector T-cell response. As in patients with chronic HBV infection, DNA vaccination failed to generate T cells that cleared infection. This model of persistent HBV infection could be used to study the pathogenesis of chronic HBV infection and develop new therapeutic strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hepatitis-b-virus; Mouse Model; In-vivo; Interferon; Expression; Clearance; Responses; Cells; Liver; Dna; Mouse Model; Liver Disease; Virology; Immunity
ISSN (print) / ISBN 0016-5085
e-ISSN 1528-0012
Zeitschrift Gastroenterology
Quellenangaben Band: 142, Heft: 7, Seiten: 1447-1450 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed