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Heinrich, J. ; Brüske, I. ; Schnappinger, M. ; Standl, M. ; Flexeder, C. ; Thiering, E. ; Tischer, C.G. ; Tiesler, C.M. ; Kohlböck, G. ; Wenig, C.M. ; Bauer, C.P.* ; Schaaf, B.* ; von Berg, A.* ; Berdel, D.* ; Krämer, U.* ; Cramer, C.* ; Lehmann, I. ; Herbarth, O.* ; Behrendt, H. ; Ring, J. ; Kühnisch, J.* ; Koletzko, S.*

Die zwei deutschen Geburtskohorten GINIplus and LISAplus.

Bundesgesundheitsbl.-Gesund. 55, 864-874 (2012)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Numerous chronic diseases in childhood and adulthood have their origins in perinatal life and are potentially influenced by trans-generational epigenetic processes. Therefore, prospective birth cohorts can substantially contribute to our knowledge about the etiology of diseases including modifiable risk factors. The two population-based German birth cohorts GINIplus and LISAplus aim to describe the natural course of chronic diseases and intermediate phenotypes in childhood and its determinants, and to identify potential genetic effect modifications. In the mid-1990s, 5,991 (GINIplus) and 3,097 (LISAplus) healthy, term newborns were recruited for long-term follow-up in four regions of Germany. The follow-up rate for the first 10 years was about 55%. We analyzed the growth and development of overweight, infections and allergic diseases, mental and oral health, metabolic and inflammatory parameters and the role of potential risk factors including genetics. The results of these two birth cohorts substantially contribute to the current knowledge about the natural course of these health parameters. These data were included in many international projects and consortia for purposes of international comparisons of prevalence and consistency of findings, and to increase the power of the analyses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Birth Cohort; Overweight; Allergy; Mental Health; Environmental Factors
ISSN (print) / ISBN 1436-9990
e-ISSN 1437-1588
Zeitschrift Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
Quellenangaben Band: 55, Heft: 6-7, Seiten: 864-874 Artikelnummer: , Supplement: ,
Verlag Springer