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Tschöp, M.H. ; Speakman, J.R.* ; Arch, J.R.S.* ; Auwerx, J.* ; Brüning, J.C.* ; Chan, L.* ; Eckel, R.H.* ; Farese, R.V.* ; Galgani, J.E.* ; Hambly, C.* ; Herman, M.A.* ; Horvath, T.L.* ; Kahn, B.B.* ; Kozma, S.C.* ; Maratos-Flier, E.* ; Müller, T.D. ; Münzberg, H.* ; Pfluger, P.T. ; Plum, L.* ; Reitman, M.L.* ; Rahmouni, K.* ; Shulman, G.I.* ; Thomas, G.* ; Kahn, C.R.* ; Ravussin, E.*

A guide to analysis of mouse energy metabolism.

Nat. Methods 9, 57-63 (2012)
Verlagsversion Volltext DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof. We hope this guide will facilitate comparisons across studies and minimize spurious interpretations of data. We recommend that division of energy expenditure data by either body weight or lean body weight and that presentation of group effects as histograms should be replaced by plotting individual data and analyzing both group and body-composition effects using analysis of covariance (ANCOVA).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mice; Obesity; Energy Metabolism; Environment; Body Composition; CHRONIC SOCIAL STRESS; DIET-INDUCED OBESITY; FAT-FREE MASS; BODY-COMPOSITION; LABORATORY MICE; FOOD-INTAKE; EXPENDITURE; TISSUE; AGE; BEHAVIOR
ISSN (print) / ISBN 1548-7091
e-ISSN 1548-7105
Zeitschrift Nature Methods
Quellenangaben Band: 9, Heft: 1, Seiten: 57-63 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus