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Frank, B.* ; Weck, M.N.* ; Müller, H.* ; Klopp, N. ; Illig, T. ; Raum, E.* ; Brenner, H.*

Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.

Eur. J. Cancer 48, 114-120 (2012)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mucins represent major components of the mucous layer in the stomach, protecting the underlying epithelium from acid, mechanical trauma, proteases and pathogenic bacteria. Previous studies have shown an association of neoplastic transformation in the stomach with aberrant mucin levels, suggesting a potential role of genetic variation in mucin genes in the development of gastric cancer (GC). We assessed the association of genetic variation in candidate single nucleotide polymorphisms (SNPs) in mucin genes with the risk of chronic atrophic gastritis (CAG), a well-established precursor of GC in the German population-based ESTHER study. We genotyped MUC1 T31T, MUC2 L58P, MUC2 V116M, MUC5B E34G, MUC5B R51W, MUC5B rs2014486 (intronic) and MUC6 V619M for 533 serologically defined CAG cases and 1054 age- and sex-matched controls. None of the analysed SNPs was associated with CAG. However, large studies are needed to disclose or exclude potential weak associations of these SNPs with CAG risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mucins ; Polymorphism ; Chronic Atrophic Gastritis ; Gastric Cancer ; Risk; HELICOBACTER-PYLORI INFECTION; PRECANCEROUS PROCESS; OLDER-ADULTS; CANCER; POPULATION; EXPRESSION; CARCINOMA; MUCINS; CARCINOGENESIS; ADENOCARCINOMA
ISSN (print) / ISBN 0959-8049
e-ISSN 1879-0852
Quellenangaben Band: 48, Heft: 1, Seiten: 114-120 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed