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Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Hepatology 55, 287-297 (2012)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Adeno-associated viral vectors (rAAV) are frequently used in gene therapy trials. Although rAAV vectors are of low immunogenicity, humoral as well as T cell responses may be induced. While the former limits vector reapplication, the expansion of cytotoxic
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Publication type Article: Journal article
Document type Scientific Article
Keywords B-VIRUS INFECTION; GENE-EXPRESSION; ACTIVATION; LIPOPOLYSACCHARIDE; HEPATOCYTES; INTERFERON; ADENOVIRUS
Reviewing status