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Typ-2-Diabetes-assoziierte Gene.

Diabetologe 8, 26-34 (2012)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Type 2 diabetes is becoming more and more important because the prevalence of the disease, which is characterized by reduced insulin sensitivity and secretion, keeps rising in the population. This dysfunction leads to a decreased glucose uptake in target tissues, whereby the blood glucose level eventually increases. In this process genetic as well as environmental factors play a role but the fundamental pathogenesis is still not fully understood. Numerous genes contributing to the manifestation have already been identified mainly via genome-wide association studies (GWAS). The main part of the heritability of type 2 diabetes as well as functional mechanisms remain unclear. The elucidation is the first step towards the development of improved as well as personalized therapeutic approaches.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Type 2 Diabetes ; Dna Variant ; Genome-wide Association Study (gwas) ; Therapy ; Gene; GENOME-WIDE ASSOCIATION; RISK; GLUCOSE; VARIANT; LOCI; SUSCEPTIBILITY; PREVENTION; OBESITY; TCF7L2; KCNQ1
ISSN (print) / ISBN 1860-9716
e-ISSN 1860-9724
Zeitschrift Diabetologe, Der
Quellenangaben Band: 8, Heft: 1, Seiten: 26-34 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed