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Mackereth, C.D.* ; Sattler, M.

Dynamics in multi-domain protein recognition of RNA.

Curr. Opin. Struct. Biol. 22, 287-296 (2012)
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Protein-RNA interactions play essential roles in gene regulation and RNA metabolism. While high-resolution structures have revealed principles of RNA recognition by individual RNA binding domains (RBDs), the presence of multiple RBDs in many eukaryotic proteins suggests additional modes of RNA recognition by combination and cooperation of these interactions. Recent structures, together with biochemical and biophysical studies have revealed novel principles of RNA recognition by multi-domain proteins. These examples highlight an important role for dynamics in RNA recognition, with mechanisms including fly-casting and conformational selection, and advocate the use of solution techniques for their analysis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter MAGNETIC-RESONANCE-SPECTROSCOPY; MOLECULAR-WEIGHT PROTEINS; EXPORT FACTOR TAP; X-RAY-SCATTERING; STRUCTURAL BASIS; NMR-SPECTROSCOPY; BINDING PROTEINS; COMPLEX REVEALS; CONFORMATIONAL SELECTION; SPLICING REGULATION
ISSN (print) / ISBN 0959-440X
e-ISSN 1879-033X
Quellenangaben Band: 22, Heft: 3, Seiten: 287-296 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed