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Fuchs, H. ; Sabrautzki, S. ; Seedorf, H.* ; Rathkolb, B. ; Rozman, J. ; Hans, W. ; Schneider, R. ; Klaften, M. ; Hölter, S.M. ; Becker, L. ; Klempt, M. ; Elvert, R. ; Wurst, W. ; Klopstock, T.* ; Klingenspor, M.* ; Wolf, E.* ; Gailus-Durner, V. ; Hrabě de Angelis, M.

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines.

Eur. J. Oral Sci. 120, 269-277 (2012)
Verlagsversion Volltext Postprint DOI
Open Access Green
We analyzed two mutant mouse lines, ATE1 and ATE2, that carry point mutations in the enamelin gene which result in premature stop codons in exon 8 and exon 7, respectively. Both mutant lines show amelogenesis imperfecta. To establish the effect of mutations within the enamelin gene on different organs, we performed a systematic, standardized phenotypic analysis of both mutant lines in the German Mouse Clinic. In addition to the initially characterized tooth phenotype that is present in both mutant lines, we detected effects of enamelin mutations on bone and energy metabolism, as well as on clinical chemical and hematological parameters. These data raise the hypothesis that enamelin defects have pleiotropic effects on organs other than the teeth.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Amelogenesis Imperfecta ; Enam ; Enamelin ; Pleiotropic Effects; Dominant Amelogenesis Imperfecta; Genome-Wide; Proteins; Mutation; Mice; Expression; Platform; Models; Tool
ISSN (print) / ISBN 0909-8836
e-ISSN 1600-0722
Quellenangaben Band: 120, Heft: 4, Seiten: 269-277 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed