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New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis.

Lancet 380, 680-688 (2012)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is characterised by altered cellular composition and homoeostasis in the peripheral lung, leading to excessive accumulation of extracellular matrix and, ultimately, loss of lung function. It is the interstitial pneumonia with the worst prognosis-mortality 3-5 years after diagnosis is 50%. During the past decade, researchers have described several novel cellular and molecular mechanisms and signalling pathways implicated in the pathogenesis of idiopathic pulmonary fibrosis, resulting in the identification of new therapeutic targets. These advances will hopefully result in increased survival rates and improved quality of life for patients with this disorder in future.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter EPITHELIAL-MESENCHYMAL TRANSITION; USUAL INTERSTITIAL PNEUMONIA; COLLAGEN-PRODUCING CELLS; PROSTAGLANDIN E-2; MYOFIBROBLAST DIFFERENTIATION; STEM-CELLS; GASTROESOPHAGEAL-REFLUX; FIBROBLASTIC FOCI; RENAL FIBROSIS; SONIC HEDGEHOG
ISSN (print) / ISBN 0140-6736
e-ISSN 0099-5355
Zeitschrift Lancet, The
Quellenangaben Band: 380, Heft: 9842, Seiten: 680-688 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed