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Bongaerts, B.W.C.* ; Rathmann, W.* ; Kowall, B.* ; Herder, C.* ; Stöckl, D. ; Meisinger, C. ; Ziegler, D.*

Postchallenge hyperglycemia is positively associated with diabetic polyneuropathy: The KORA F4 study.

Diabetes Care 35, 1891-1893 (2012)
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OBJECTIVE-To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes. RESEARCH DESIGN AND METHODS-Glucose tolerance status was determined in 61- to 82-year-old participants (n = 1,100) of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 Survey (2006-2008). Clinical DSPN was defined as bilaterally impaired foot-vibration perception and/or foot-pressure sensation. RESULTS-Prevalence of clinical DSPN was similar in subjects with known diabetes (22.0%) and subjects with combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) (23.9%). Among prediabetic subgroups, IFG-IGT, but not isolated-IFG and -IGT, was associated with a higher risk of clinical DSPN, compared with normal glucose tolerance. A J-shaped association was observed between clinical DSPN and quartiles of 2-h postchallenge glucose, but not with fasting glucose and HbA(1c) levels. CONCLUSIONS-Subjects with IFG-IGT and known diabetes had a similar prevalence of clinical DSPN. Elevated 2-h postload glucose levels appeared important for disease risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Augsburg Surveys S2; Mellitus; Prevalence; Neuropathy; Risk; Complications; Glucose; S3
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 35, Issue: 9, Pages: 1891-1893 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed