PuSH - Publikationsserver des Helmholtz Zentrums München

Eickholz, P.* ; Kim, T.-S.* ; Bürklin, T.* ; Schacher, B.* ; Renggli, H.H.* ; Schaecken, M.T.* ; Holle, R. ; Kübler, A.* ; Ratka-Krüger, P.*

Non-surgical periodontal therapy with adjunctive topical doxycycline : A double-blind randomized controlled multicenter study. (I). Study design and clinical results.

J. Clin. Periodontol. 29, 108-117 (2002)
Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Aim: Evaluation of the clinical effect of topical application of doxycycline adjunctive to non-surgical periodontal therapy.Methods: A total of 111 patients suffering from untreated or recurrent moderate to severe periodontitis at 3 different centers (Heidelberg, Frankfurt, Nijmegen) were treated in this double-blind split-mouth study. In each patient, 3 different treatment modalities were assigned randomly to 3 test teeth: scaling and root planing alone (SRP), SRP with subgingival vehicle control (VEH), and SRP with subgingival application of a newly developed biodegradable 15% doxycycline gel (DOXI). At baseline, clinical parameters were measured at all single rooted teeth using a reference splint: PlI, PPD, relative attachment level (RAL-V), GI. 3 strata were generated according to baseline PPD: (i) 5-6 mm, (ii) 7-8 mm, (iii) greater than or equal to9 mm. Not more than 50% active smokers were allowed to each stratum. 3 and 6 months after therapy re-examination was performed by examiners blinded to baseline data and test sites. The statistical comparison of RAL-V gain and PPD reduction between the treatments was based on a repeated measures ANOVA with correction according to Huynh & Feldt. The comparison of SRP versus DOXI was considered as the main study question.Results: 110 patients finished the 3 months and 108 the 6 months examination. The study did not show adverse effects of VEH or DOXI except for one singular inflammation that occurred 2 months after application of the doxycycline gel. DOXI provided statistically significantly more favorable PPD reduction (SRP: -2.4+/-1.4 mm, VEH: -2.7+/-1.6 mm, DOXI: -3.1+/-1.2 mm; SRP versus DOXI VEH versus DOXI p=0.0066) and RAL-V gain (SRP: 1.6+/-1.9 mm, VEH: 1.6+/-2.2 mm, DOXI: 2.0+/-1.7 mm; SRP versus DOXI p=0.027, VEH versus DOXI p=0.038) than SRP and VEH after 6 months.Conclusions: Adjunctive topical subgingival application of a biodegradable 15% doxycycline gel was safe and provided more favorable RAL-V gain and PPD reduction than SRP alone and VEH. Thus, by use of topical doxycycline the threshold for surgical periodontal therapy might be moved toward deeper pockets.
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter topical subgingival doxycycline; biodegradable controlled release device; nonsurgical periodontal therapy; double blind randomized controlled multicenter clinical trial
ISSN (print) / ISBN 0303-6979
e-ISSN 1600-051X
Zeitschrift Journal of Clinical Periodontology
Quellenangaben Band: 29, Heft: , Seiten: 108-117 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus