Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nat. Genet. 42, 430-435 (2010)
DOI Verlagsversion bestellen
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide association; Type-2 diabetes risk; Gestational-age; Head Circumference; Adenylyl-cylase; Cohort; Gene; Metaanalysis; Expression; Isoforms
ISSN (print) / ISBN 1061-4036
Zeitschrift Nature Genetics
Quellenangaben Band: 42, Heft: 5, Seiten: 430-435
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology I (EPI1)