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Adler, I.-D. ; Andrae, U. ; Kreis, P.* ; Neumann, H.-G.* ; Thier, R.* ; Wild, D.*

Recommendations for the categorization of germ cell mutagens.

Int. Arch. Occup. Environ. Health 73, 428-432 (2000)
Open Access Green as soon as Postprint is submitted to ZB.
Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remain unchanged. Two new categories 3A and 3B are proposed for chemicals suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency that contribute negligibly to human genetic risk provided the MAK value is observed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords germ cell mutagens; list of MAK and BAT values; genetic risk
ISSN (print) / ISBN 0340-0131
e-ISSN 1432-1246
Quellenangaben Volume: 73, Issue: 6, Pages: 428-432 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed