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Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
Ann. Med. 41, 128-138 (2009)
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Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174GC and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174GC polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Blood glucose; body mass index; diabetes mellitus type 2; genes; inflammation mediators; interleukin-6; intermediate phenotype; meta-analysis; molecular epidemiology; single nucleotide polymorphism; g/c promoter polymorphism; type-2 diabetes-mellitus; myocardial-infarction; gene promoter; risk-factors; plasma interleukin-6; metabolic syndrome; metaanalysis; obesity; cohort
ISSN (print) / ISBN 0785-3890
Zeitschrift Annals of Medicine
Quellenangaben Band: 41, Heft: 2, Seiten: 128-138
Verlag Informa Healthcare
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology I (EPI1)