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Erdmann, J.* ; Grosshennig, A.* ; Braund, P.S.* ; König, I.R.* ; Hengstenberg, C.* ; Hall, A.S.* ; Linsel-Nitschke, P.* ; Kathiresan, S.* ; Wright, B.* ; Trégouët, D.-A.* ; Cambien, F.* ; Bruse, P.* ; Aherrahrou, Z* ; Wagner, A.K.* ; Stark, K.* ; Schwartz, S.M.* ; Salomaa, V.* ; Elosua, R.* ; Melander, O.* ; Voight, B.F* ; O'Donnell, C.J.* ; Peltonen, L.* ; Siscovick, D.S.* ; Altshuler, D.* ; Merlini, P.A.* ; Peyvandi, F.* ; Bernardinelli, L.* ; Ardissino, D.* ; Schillert, A.* ; Blankenberg, S.* ; Zeller, T.* ; Wild, P.* ; Schwarz, D.F.* ; Tiret, L.* ; Perret, C.* ; Schreiber, S.* ; El Mokhtari, N.E.* ; Schäfer, A.* ; Marz, W.* ; Renner, W.* ; Bugert, P.* ; Klüter, H.* ; Schrezenmeir, J.* ; Rubin, D.* ; Ball, S.G* ; Balmforth, A.J.* ; Wichmann, H.-E. ; Meitinger, T. ; Fischer, M.* ; Meisinger, C. ; Baumert, J.J. ; Peters, A. ; Ouwehand, W.H.* ; Deloukas, P.* ; Thompson, J.R.* ; Ziegler, A.* ; Samani, N.J.* ; Schunkert, H.*

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

Nat. Genet. 41, 280-282 (2009)
DOI Order publishers version
Open Access Green as soon as Postprint is submitted to ZB.
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
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Publication type Article: Journal article
Document type Scientific Article
Keywords association; genome
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 3, Pages: 280-282 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed