Multi-omic signature of body weight change: Results from a population-based cohort study.
Wie Gewichtsveränderungen den menschlichen Stoffwechsel beeinflussen
How Changes in Body Weight Affect the Human Metabolism
||Simone Wahl, Susanne Vogt||Publication
We comprehensively characterized metabolic consequences of body weight changes in the population-based KORA S4/F4 cohort using multiple omics data from two metabolomics and one transcriptomics platform. We observed a global effect of weight change on the serum metabolome, and an effect on selected gene transcripts. Our findings improve the understanding of molecular mechanisms underlying the association of weight gain with changes in lipid and amino acid metabolism, insulin sensitivity, mitochondrial function as well as blood cell development and function.
Core statement Pressemitteilung:
Neuherberg, Germany, 09 March 2014. The proportion of overweight people is steadily rising in Germany, leading to an increase in the number of patients later diagnosed with cardiovascular diseases, dyslipidemia or diabetes. In a just-published study in the journal BMC Medicine, scientists of Helmholtz Zentrum München report on the long-term effects of changes in body weight on the metabolism.
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