PuSH - Publication Server of Helmholtz Zentrum München

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A divergent population of autoantigen-responsive CD4(+) T cells in infants prior to β cell autoimmunity.

Titel Pressemitteilung:

Bestimmte T-Zellen in Neugeborenen weisen auf Typ-1-Diabetes hin

T cells in babies give clues to who will develop type 1 diabetes

Apr 2017 ICB
Prof. Dr. Anette-Gabriele Ziegler PDF WB 2017-06-01
AR 2017-07-01
PR 2017-02-01
Core statement:

Susceptibility to type 1 diabetes involves genetic risk factors and potential environmental triggers, making it harder to predict which individuals will actually develop disease. Longitudinal samples collected starting shortly after birth from children at risk for type 1 diabetes were examined by Heninger et al. to scrutinize early immune responses. Some, but not all, of these children eventually developed autoimmunity; CD4+ T cells from those that progressed had a distinct phenotype after presentation of autoantigen, suggesting that they had already been somewhat activated, even before autoantibodies were detectable. These exciting findings indicate that cues that dictate type 1 diabetes development may be happening even earlier than expected, in infancy.

Core statement Pressemitteilung:

Gemeinsam mit Kollegen des Helmholtz Zentrums München hat eine Forschergruppe am DFG-Forschungszentrum für Regenerative Therapien Dresden (CRTD) hat ein neues Verständnis für zelluläre Mechanismen im Typ-1-Diabetes vorgestellt. Grundlage zu der Studie in ‚Science Translational Medicine‘ sind Untersuchungen an Neugeborenen, die ein hohes Risiko haben, an Diabetes-Typ-1 zu erkranken.

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