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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

Ribosomal mutations cause p53-mediated pleiotropic effects

Oct 2008 IEG
HDC
SAM
G-500600-003
Fuchs PDF
PM DE: PDF
PM EN: PDF
Publikation
Core statement:

We have characterized highly unexpected pleiotropic gene functions caused by mutations in ribosomal proteins that are mediated by the tumour suppressor gene p53 which lead to anemia and altered pigmentation of the skin in mice; these mutant mice model Diamond-Blackfan syndrome.

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