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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Apr 2009 Wichmann PDF
PM DE: PDF
PM EN: PDF
PR 2009-02-01
Publikation
Publikation
Publikation
Core statement:

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approx25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 times 10-13; OR = 1.15, 95% CI = 1.11–1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 times 10-7; OR = 1.08, 95% CI = 1.05–1.11).

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