PuSH - Publikationsserver des Helmholtz Zentrums München

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Abfrage Programm/Institut/Gruppe PSP-Element Kontakt Anhang Verwendung Publikation
Titel:

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

Oct 2009 K.MOLBI
EH
G-501400-001
Eick PDF
PM DE: PDF
PM EN: PDF
PR 2009-06-01
Publikation
Core statement:

Posttranslational modifications of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) specify a molecular recognition code that is deciphered by proteins involved in RNA biogenesis. The CTD is comprised of a repeating heptapeptide (Y(1)S(2)P(3)T(4)S(5)P(6)S(7)). Recently, phosphorylation of serine 7 was shown to be important for cotranscriptional processing of two snRNAs in mammalian cells. Here we report that Kin28/Cdk7, a subunit of the evolutionarily conserved TFIIH complex, is a Ser7 kinase. The ability of Kin28/Cdk7 to phosphorylate Ser7 is particularly surprising because this kinase functions at promoters of protein-coding genes, rather than being restricted to promoter-distal regions of snRNA genes. Kin28/Cdk7 is also known to phosphorylate Ser5 residues of the CTD at gene promoters. Taken together, our results implicate the TFIIH kinase in placing bivalent Ser5 and Ser7 marks early in gene transcription. These bivalent CTD marks, in concert with cues within nascent transcripts, specify the cotranscriptional engagement of the relevant RNA processing machinery.

Titel:

CTD kinase for Serine 7 identified

Apr 2009 K.MOLBI
EH
G-501400-001
Eick PDF
PM DE: PDF
PM EN: PDF
Publikation
Publikation
Publikation
Publikation
Core statement:

Identification of the kinase for RNA Polymerase II carboxy-terminal domain Serine 7 phosphorylation in yeast and mammals

Titel:

New Piece Found in the Puzzle of Epigenetics - Researchers of Helmholtz Zentrum München elucidate mechanism of the fine regulation of RNA synthesis

Apr 2009 K.MOLBI
EH
G-501400-001
Eick PDF
PM DE: PDF
PM EN: PDF
PR 2009-06-01
Publikation
Core statement:

Neuherberg, June 16, 2009. A team of scientists led by Professor Dirk Eick of Helmholtz Zentrum München has identified the enzyme TFIIH kinase as an important factor in the epigenetic regulation of the cell nucleus enzyme RNA polymerase II. The findings, recently published in the renowned journal Molecular Cell, constitute a further building block for understanding the pathomechanisms of cancer and other diseases.

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